Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Having reached the current stage of development, China can now advance only through reform and innovation. We have the largest quality workforce as well as the largest pool of scientists, engineers and professionals in the world, and their potential for innovation is truly tremendous.
Trends and targets in antiviral phototherapy
Apple Chief Executive Officer Steve Jobs holds the new " iPad" during the launch of Apple's new tablet computing device in San Francisco, California, in this January 27, 2010
But if the U.S. can avert that Washington-made crisis, the outlook for workers finding jobs is actually looking pretty good for next year. For one thing, the damage of superstorm Sandy will have to be repaired, meaning jobs in construction and retail. Businesses, meanwhile, which have held off investing and hiring because of uncertainty over the fiscal outlook, might finally open their wallets. That means more jobs, too.[qh]
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Financial advisors and asset allocators who had been hoping to see some benefit this year from tactical strategies were also not spared the punishment of a capricious market. Of the top three tactical strategies in the country (Mainstay Marketfield, Good Harbor U.S. Tactical Core, F-Squared Premium AlphaSector Index), two had nearly imploded with double-digit losses while the third found itself under SEC investigation for misleading the public about its historical returns. The other giant tactical manager, Schwab’s $9 billion Windhaven Diversified Growth product, looks to end 2014 with a return close to zero. So much for tactics.
ACE2 as a potential therapeutic target for pandemic COVID-19
Sport dominated the trending searches, with Euro 2012 and Olympic tickets showing the biggest rises in interest ahead of Houston and the Duchess of Cambridge.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
This year's juries were chaired by AFI board of trustees vice chairs Tom Pollock (for film) and Richard Frank (for TV). Other jury members included Judd Apatow, Halle Berry, Jamie Lee Curtis, Leonard Maltin, authors and scholars representing prestigious universities with recognized motion picture arts and TV programs and film and TV critics from media outlets like NPR, Rolling Stone, TV Guide and The Washington Post.
That's not even a sarcastic quip, it's the truth.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
2. 达美乐（Dachis） 品牌喜爱度：-11%/排名：62
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Only the US-based MIT Sloan School of Management, in fifth place, prevented French institutions from sweeping the top five positions.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Remember, no one is ever perfectly prepared for every situation. You’ve probably discovered this by now. Your education gave you a foundation for the job, but growth happens in the trenches. Maybe you motivated your team not just to meet the new deadline, but to deliver extraordinary work. Perhaps you realized you had more poise than you ever expected in a client situation. Or, you suddenly discovered that you can capitalize on the relationships you’ve built and become a “rainmaker” for your organization. Before you can learn any of these things, you have to learn to say “Yes.” It’s okay to acknowledge the butterflies in your stomach; however, it’s not okay to let them stifle your growth.
A lot of the best James Bond theme songs sound like they belong in a lounge act. That's not a complaint, just an observation. For whatever reason, the English new wave act Duran Duran was given free reign to provide A View to a Kill with a new and exciting sound all its own. "A View to a Kill" was a hit song, and it probably would have been a success even without the James Bond connection. It's entertaining and cool and energetic, and it promises one hell of a good time. (Whether or not the movie actually lives up to that promise is a matter of some debate.)
Influenza neuraminidase: A druggable target for natural products
“我想不出还有哪家公司抵挡住了对冲基金丛林中两头最凶猛的猛兽的攻击，”加州公务员退休基金的辛普森说，“他很酷，很冷静，泰然自若，是‘保持冷静，继续前进(Keep calm and carry on)’这句话在企业界的模范体现。”
2013 Rank: 12
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
当时，身为首席执行官的库克也承受着压力，因为苹果除了从iPhone攫取利润之外，缺乏清晰的产品开发方向。维权投资者嗅到了血腥，开始围攻这家公司，打头的是大卫?艾因霍恩(David Einhorn)，接着是卡尔?伊坎(Carl Icahn)，他们游说改变苹果的经营和财务管理方式。伊坎施压要求苹果筹集巨额债务，向股东返还1500亿美元，并敦促苹果发布包括电视机在内的更多产品。
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Will impeachment proceedings begin against Donald Trump
It is revealed that Hadid's visa application was turned down after she offended many by squinting her eyes in an attempt to impersonate the Buddha in February.
We need to ensure that our consumers will have access to good options, benefit from such consumption, and most importantly that Chinese companies will be able to win over the consumers with their commitment to high quality and workmanship.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
"Although it may seem counterintuitive, the best way to maximize profits over the long-term is not to make them the primary goal of the business," Mackey said in an interview earlier this year.
A shortage of qualified supply chain managers right now, especially in global companies that must coordinate far-flung operations, can be traced to two factors.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Scientists may be working hard at making organs that match the body's capabilities, but why stop there?
Inhibition of SARS coronavirus helicase by bismuth complexes
一部富有感染力的、描写一名年轻黑人男同性恋成长故事的影片《月光男孩》(Moonlight)，获得2017年奥斯卡(Oscar)最佳影片奖。不过，该片险些与此奖项擦肩而过，原因是在混乱的颁奖现场，此奖项曾被误颁给了《爱乐之城》(La La Land)。
Christine "Lady Bird" MacPherson is a high school senior from the "wrong side of the tracks." She longs for adventure, sophistication, and opportunity, but finds none of that in her Sacramento Catholic high school. Lady Bird follows the title character's senior year in high school, including her first romance, her participation in the school play, and most importantly, her applying for college.
If the oldest man ever elected president can “tweet like a kindergartner,” why not flip the script and see if a youngster can be elected to office and govern wisely?
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Had the North Koreans not set off another nuclear test at the weekend the big story this week on the Korean peninsula might have been the Trump administration’s odd timing in announcing its plans to pull out of a trade deal with Seoul.
He admitted to having mixed emotions about the letter as he and Vonnie are now divorced.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
For newcomers, these changes provide fresh housing options. But for residents, they can spell displacement. The same is true for shops such as De Robertis Pasticceria and Caffe in the East Village, which just closed after a 110-year run. And next year, the Union Square Cafe will likely conclude its 30 years in Union Square.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
However they went ahead with plans to send 100,000 anti-Pyongyang leaflets.
Since 2005, the business book of the year award has gone to the book that provides “the most compelling and enjoyable insight into modern business issues”. The 2014 winner was Capital in the Twenty-First Century by Thomas Piketty.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
However, others argued that doctors' hands may be forced by an unfair system. "As a patient, I'm more concerned about whether they can cure my illness rather than how many papers they've published," another netizen said.
会。美国政府在垂直合并案上已有数十年没赢过。据美国司法部(Department of Justice)自己的审查指导原则，像时代华纳这样的内容所有者与AT&T这样的分销商之间的“垂直合并”，远不如水平合并那么令人担忧。与此同时，Facebook、亚马逊(Amazon)、Netflix和谷歌(Google)这四巨头（合称FANG，取每家名称首字母）如今主宰了数字娱乐版图，这使得政府的如下论点更难以站住脚：两家传统媒体公司的合并，会从根本上改变竞争态势。
Finding the skill sets and attitudes that support the culture of the brand you want to promote will foster innovation and enhance your reputation. Include folks from outside the company for the people you rely on. That will start a free marketing chain reaction that can build confidence and revenue.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
In January, Wal-Mart (WMT, Fortune 500) U.S. president And CEO Bill Simon pledged that the world's largest retailer would hire 100,000 veterans over the next five years. In addition, the biggest private employer in the U.S. said it would offer employment to any honorably discharged veteran within his or her first 12 months off active duty.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
9. Occupational therapist
8.My resume is 5 pages long for a good reason. – Because I’m darn good at bullshittin’!
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Estimates vary, but the research firm IDC projects that wearable tech will exceed 19 million units this year—more than triple last year’s sales—and will soar to 111.9 million units by 2018. Credit Suisse values the industry at somewhere between $30 billion and $50 billion in the next two to four years. But before that happens, the nascent market has that pesky wouldn’t-be-caught-dead-wearing-it hurdle to clear.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The students were very experienced, commented one graduate. Networking and interaction among everyone involved were key aspects of this programme.
Emma Morano’s singular achievement in life may have been perseverance. She lived for 117 years, crediting her longevity to raw eggs and her lack of a husband. She died on April 15.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Directing for a Comedy Series: Jill Soloway, “Transparent” (“Man on the Land”)
They must understand in their bones that it is illegitimate to make temporary power permanent by rigging elections, suppressing contrary opinions or harassing the opposition.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
尽管英国商学院的排名平均上升了两位，但法国商学院的排名平均下降了一位——法国是商学院数量最多的欧洲国家。里昂商学院(EMLyon Business School)由于跌出MBA榜单之外，整体排名下降了15位，同时北方高等商学院(Edhec Business School)由于未能进入EMBA榜单，整体排名下降了8位。
If 2017 was the year policymakers began to worry about the growth of the “precariat”, 2018 will be the year they try to do something about it.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The US has the most universities of any country in the overall ranking, with 221 schools earning a spot. The countries with the next-highest numbers of schools in the ranking are China and Japan with 136 and 76, respectively.
However, its alumni are the most mobile internationally, with 85 per cent of the class of 2014 having worked abroad.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Such insights are of particular interest to litigation funders, who back claimants in return for a cut of damages and who try to assess the likely outcomes of disputes before committing their money. But that may have to be 2019’s breakthrough, or probably beyond.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
His eloquent defence of equality came after a year of faltering progress on gay marriage in the US and as arguments rage about the lack of diversity among the people running the Silicon Valley companies, including Apple, who shape so much of our culture.
On Tuesday Saarland became the first German region to ban campaigning by foreign politicians. Several German local councils had called off planned Turkish ministers’ campaign meetings on technical grounds, such as fire safety.
A modular microarray imaging system for highly specific COVID-19 antibody testing
China Hyundai dealers seek up to $135 million compensation
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
The new numbers, reported by a tracking initiative called the Global Carbon Project and published in the journal Nature Geoscience, came on the eve of a United Nations summit meeting meant to harness fresh political ambition in tackling climate change. Scientists said the figures showed that vastly greater efforts would be needed to get long-term global warming within tolerable limits.
然而，主要榜单上的排名大幅上升不会自动转化为欧洲商学院排名的上升。例如，牛津大学(University of Oxford)萨伊德商学院(SaBusiness School)在MBA榜单上的排名上升1位，在开放招生EMBA课程的排名上升5位，在EMBA榜单上的排名上升12名，首次进入该榜单前十名，但其在欧洲商学院榜单上的排名没有变化，依然是第10名。
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
And regarding Ukraine, the Russian president again denied that there are Russian troops operating inside eastern Ukraine where a pro-Russian separatist movement is fighting Ukrainian government troops. But he said Moscow never denied that "certain people" were there carrying out tasks "in the military sphere." He said Russia plans no sanctions against Ukraine, but will not extend preferential trade to Kyiv.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Despite the fact that each market rebound ended up as a V-shaped affair, each successive rally was carried out with less and less individual stock participation. Glaring divergences between winners and losers, large caps and small caps, preoccupied the commentariat for most of the spring and summer. Deflationary concerns from Europe and the Japanese technical recession further confounded analysts, as Treasury yields and inflation indicators in the U.S. were driven lower despite the improving domestic economy.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Create a mood board for inspiration, including quotes and pictures that will invigorate your creative juices. You might even want to change it up once and a while if you have a major project due or need fresh ideas. Art or wall décor can also add a creative touch to your workspace. We recommend the 3 in 1 Board, $19.95, at CB2.com (pictured above).
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Major areas of work for 2017
THE NIGHTLY SHOW WITH LARRY WILMORE (Comedy Central, Jan. 19) Mr. Wilmore’s topical comedy show replaces “The Colbert Report” at 11:30 p.m. and represents the latest opportunity to introduce some diversity to late-night programming. No pressure there!
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
"No one really knows how (end times) would look and how God would bring it about," Cox said.
This is BBC Sherlock, so your Watson isn’t stupid. He's rather smart in his own way and insecure about his sexuality (probably straight).
伦敦商学院(London Business School，见上图)荣登2014年英国《金融时报》欧洲商学院排行榜榜首，该学院上一次夺得冠军宝座是在2005年。法国巴黎高等商学院(HEC Paris)和西班牙企业商学院(IE Business School)分列二、三位。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Cross talk “Do Not Blame Me” (Cao Yunjin and Liu Yuntian)
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
ESCP Europe and MIT Sloan School of Management in the US also performed well. Both schools climbed five places into third and fifth place respectively.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Cross talk (Guo Degang and Yu Qian)
Play up being smarter than everyone, develop some obvious insecurities. Forget social skills if you happen to have any.
Length-scale dependence of protein hydration-shell density
On Monday night, Ankara confirmed that the Dutch ambassador would not be welcome to return to Turkey.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
In Canada, we live the privileged life, with plenty of food, water and shelter—we have watches, bicycles, computers and television sets. 在加拿大，他们过着特权般的生活，他们有很多食物、房子和水。他们拥有很多手表，汽车，各种电器和奢侈品。
In the month since her death, police have not said whether she accidentally pulled the trigger or was shot by someone else in the room.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The banks' ability to return money to shareholders have declined. The slowing earning growth, high nonperforming loans and required deposits on the reserve have placed pressure on the banks in regards to capital supplement, said Guo Tianyong, director of the China Banking Research Center at the Central University of Finance and Economics.
“We miss a heck of a lot of people,” Mr Hoogewerf told the Financial Times. “I was in Beijing two weeks ago and visited this investment company. In the space of one afternoon I discovered 30 people who went on to our rich list this year. Last year they were under our radar.”
About this collection
2013 Rank: 3
On our increasingly human-dominated planet we can still learn much from the lives of other species. The discovery this year that the Greenland shark lives for 400 years, making it the longest-living vertebrate, puts our hectic lives into perspective.